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non small cell lung cancer nsclc a549 cell line  (ATCC)


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    ATCC non small cell lung cancer nsclc a549 cell line
    Non Small Cell Lung Cancer Nsclc A549 Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 31985 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/non+small+cell+lung+cancer+cell+lines+a549/A549/pm42320477-244-0-8
    Average 99 stars, based on 31985 article reviews
    non small cell lung cancer nsclc a549 cell line - by Bioz Stars, 2026-09
    99/100 stars

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    Mutagenesis:

    Article Title: Synthesis and anti-lung cancer evaluation of fused pyrazolo[3,4-b]pyridine linked isoxazoles and 1,2,3-triazoles: PEG-400 mediated one-pot reaction under microwave irradiation.
    Article Snippet: Lung cancer remains one of the leading causes of cancer-related mortality worldwide, and dysregulation of the epidermal growth factor receptor (EGFR) signaling pathway plays a central role in its progression.. In the present study, a novel series of fused isoxazole and fused 1,2,3-triazole derivatives (4a–4 h and 5a–5 h) were rationally designed, synthesized and evaluated for their anticancer potential against human lung cancer cells.. These compounds were synthesized via a single-step [3 + 2] cycloaddition reaction using (Z)-1-(4-fluorophenyl)-N-(4iodobut-3-yn-2-ylidene)-3-methyl-1H-pyrazol-5-amine as the key precursor.

    Article Title: HIF-1α siRNA Enhances the Efficacy of Erlotinib in Non-small Cell Lung Cancer: A Novel Strategy to Reverse Hypoxia-Induced Drug Resistance.
    Article Snippet: Item Company City, country Catalog no. Erlotinib Titan Scientific Co., Ltd. Shanghai, China 041178861 Small interfering RNA TsingKe Biotech Co., Ltd. Beijing, China NA siRNA-mate Plus Transfection Kit GenePharma Co., Ltd. Suzhou, China G04026 ABScript III RT Master Mix for qPCR with gDNA Remover Aibotek Biotechnology Co., Ltd. Wuhan, China RK20429 ABScript II One Step SYBR Green RT-qPCR Kit Aibotek Biotechnology Co., Ltd. Wuhan, China RK20404 RIPA lysis buffer Beyotime Biotech Inc. Shanghai, China P0013B BCA protein assay kit Beyotime Biotech Inc. Shanghai, China P0012 SDS-PAGE gel preparation kit Beyotime Biotech Inc. Shanghai, China P0012A PVDF membranes Beyotime Biotech Inc. Shanghai, China FFP71 L-lactate assay kit Beyotime Biotech Inc. Shanghai, China S0208S HIF-1α antibody Cell Signaling Technology, Inc. Danvers, MA, USA 3716S β-Actin antibody Cell Signaling Technology, Inc. Danvers, MA, USA 4967S Item Company City, country Catalog no. β-Actin rabbit mAb (HRP conjugate) Cell Signaling Technology, Inc. Danvers, MA, USA 5125S Cell Counting Kit-8 Yeasen Biotechnology Co., Ltd. Shanghai, China 40203ES80 Transwell Chambers Corning Inc. Corning, NY, USA 3401 DAPI staining reagent Merck KGaA Darmstadt, Germany 28718-90-3 HIF-1α hypoxia-inducible factor-1α, HRP horseradish peroxidase, mAb monoclonal antibody, NA not applicable, qPCR quantitative polymerase chain reaction .. The human embryonic lung fibroblast cell line MRC-5 (RRID: CVCL_0440) and the non-small cell lung cancer cell lines A549 (KRAS mutation, EGFR wild-type, RRID: CVCL_0023) and H1975 (L858R and T790M mutations, RRID: CVCL_1511) were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences (China), originally provided by the American Type Culture Collection, where these lines were authenticated using morphology, karyotyping, and polymerase chain reaction (PCR)-based approaches and tested for mycoplasma. ..

    Polymerase Chain Reaction:

    Article Title: HIF-1α siRNA Enhances the Efficacy of Erlotinib in Non-small Cell Lung Cancer: A Novel Strategy to Reverse Hypoxia-Induced Drug Resistance.
    Article Snippet: Item Company City, country Catalog no. Erlotinib Titan Scientific Co., Ltd. Shanghai, China 041178861 Small interfering RNA TsingKe Biotech Co., Ltd. Beijing, China NA siRNA-mate Plus Transfection Kit GenePharma Co., Ltd. Suzhou, China G04026 ABScript III RT Master Mix for qPCR with gDNA Remover Aibotek Biotechnology Co., Ltd. Wuhan, China RK20429 ABScript II One Step SYBR Green RT-qPCR Kit Aibotek Biotechnology Co., Ltd. Wuhan, China RK20404 RIPA lysis buffer Beyotime Biotech Inc. Shanghai, China P0013B BCA protein assay kit Beyotime Biotech Inc. Shanghai, China P0012 SDS-PAGE gel preparation kit Beyotime Biotech Inc. Shanghai, China P0012A PVDF membranes Beyotime Biotech Inc. Shanghai, China FFP71 L-lactate assay kit Beyotime Biotech Inc. Shanghai, China S0208S HIF-1α antibody Cell Signaling Technology, Inc. Danvers, MA, USA 3716S β-Actin antibody Cell Signaling Technology, Inc. Danvers, MA, USA 4967S Item Company City, country Catalog no. β-Actin rabbit mAb (HRP conjugate) Cell Signaling Technology, Inc. Danvers, MA, USA 5125S Cell Counting Kit-8 Yeasen Biotechnology Co., Ltd. Shanghai, China 40203ES80 Transwell Chambers Corning Inc. Corning, NY, USA 3401 DAPI staining reagent Merck KGaA Darmstadt, Germany 28718-90-3 HIF-1α hypoxia-inducible factor-1α, HRP horseradish peroxidase, mAb monoclonal antibody, NA not applicable, qPCR quantitative polymerase chain reaction .. The human embryonic lung fibroblast cell line MRC-5 (RRID: CVCL_0440) and the non-small cell lung cancer cell lines A549 (KRAS mutation, EGFR wild-type, RRID: CVCL_0023) and H1975 (L858R and T790M mutations, RRID: CVCL_1511) were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences (China), originally provided by the American Type Culture Collection, where these lines were authenticated using morphology, karyotyping, and polymerase chain reaction (PCR)-based approaches and tested for mycoplasma. ..



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    IFN-γ responsiveness correlates DNA damage and repair responses in NSCLC cell lines (A) Relative cell viability of A549 <t>or</t> <t>PC-9</t> treated with the indicated concentration of IFN-γ for 24 h are shown. Data are presented as mean ± SD. (B) Reactome analysis of the GSE180942 dataset was performed using differential CRISPR β-scores under IFN-γ treatment (Δβ = PC-9 − A549). Bars indicate the normalized enrichment score (NES) for each pathway indicated. Positive NES denotes pathways whose constituent genes are more essential in A549, whereas negative NES denotes pathways more essential in PC-9 upon IFN-γ treatment.
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    IFN-γ responsiveness correlates DNA damage and repair responses in NSCLC cell lines (A) Relative cell viability of A549 or PC-9 treated with the indicated concentration of IFN-γ for 24 h are shown. Data are presented as mean ± SD. (B) Reactome analysis of the GSE180942 dataset was performed using differential CRISPR β-scores under IFN-γ treatment (Δβ = PC-9 − A549). Bars indicate the normalized enrichment score (NES) for each pathway indicated. Positive NES denotes pathways whose constituent genes are more essential in A549, whereas negative NES denotes pathways more essential in PC-9 upon IFN-γ treatment.

    Journal: Biochemistry and Biophysics Reports

    Article Title: ATM inhibition restores IFN-γ sensitivity and induces ferroptosis in NSCLC via DNA damage response

    doi: 10.1016/j.bbrep.2026.102568

    Figure Lengend Snippet: IFN-γ responsiveness correlates DNA damage and repair responses in NSCLC cell lines (A) Relative cell viability of A549 or PC-9 treated with the indicated concentration of IFN-γ for 24 h are shown. Data are presented as mean ± SD. (B) Reactome analysis of the GSE180942 dataset was performed using differential CRISPR β-scores under IFN-γ treatment (Δβ = PC-9 − A549). Bars indicate the normalized enrichment score (NES) for each pathway indicated. Positive NES denotes pathways whose constituent genes are more essential in A549, whereas negative NES denotes pathways more essential in PC-9 upon IFN-γ treatment.

    Article Snippet: The human non-small cell lung cancer cell lines PC-9 (kindly gifted from Dr. Kiura, Okayama University, Japan) and A549 (CCL-185, obtained from American Type Culture Collection) were used.

    Techniques: Concentration Assay, CRISPR

    Inhibition of ATM restores NSCLC cells to IFN-γ by inducing DNA damage response (A) Cell viability of A549 (left panel) or PC-9 (right panel) treated with IFN-γ (1000 ng/ml) and/or KU-55933 (10 μM) for 24 h are shown. Data are presented as mean ± SD. * p < 0.05. (B) Expression of γH2AX and b-Actin (loading control) in A549 (left panel) or PC-9 (right panel) cells treated with IFN-γ (1000 ng/ml) and/or KU-55933 (10 μM) for 24 h are shown.

    Journal: Biochemistry and Biophysics Reports

    Article Title: ATM inhibition restores IFN-γ sensitivity and induces ferroptosis in NSCLC via DNA damage response

    doi: 10.1016/j.bbrep.2026.102568

    Figure Lengend Snippet: Inhibition of ATM restores NSCLC cells to IFN-γ by inducing DNA damage response (A) Cell viability of A549 (left panel) or PC-9 (right panel) treated with IFN-γ (1000 ng/ml) and/or KU-55933 (10 μM) for 24 h are shown. Data are presented as mean ± SD. * p < 0.05. (B) Expression of γH2AX and b-Actin (loading control) in A549 (left panel) or PC-9 (right panel) cells treated with IFN-γ (1000 ng/ml) and/or KU-55933 (10 μM) for 24 h are shown.

    Article Snippet: The human non-small cell lung cancer cell lines PC-9 (kindly gifted from Dr. Kiura, Okayama University, Japan) and A549 (CCL-185, obtained from American Type Culture Collection) were used.

    Techniques: Inhibition, Expressing, Control

    Inhibition of ATM in combination with IFN-γ induce ferroptosis in NSCLCs Cell viability of A549 (A) or PC-9 (B) treated with the indicated combination of IFN-γ (1000 ng/ml), KU-55933 (10 μM), Ferrostatin-1 (5 μM), and Liproxstatin-1 (5 μM) for 24 h are shown. Data are presented as mean ± SD. * p < 0.05.

    Journal: Biochemistry and Biophysics Reports

    Article Title: ATM inhibition restores IFN-γ sensitivity and induces ferroptosis in NSCLC via DNA damage response

    doi: 10.1016/j.bbrep.2026.102568

    Figure Lengend Snippet: Inhibition of ATM in combination with IFN-γ induce ferroptosis in NSCLCs Cell viability of A549 (A) or PC-9 (B) treated with the indicated combination of IFN-γ (1000 ng/ml), KU-55933 (10 μM), Ferrostatin-1 (5 μM), and Liproxstatin-1 (5 μM) for 24 h are shown. Data are presented as mean ± SD. * p < 0.05.

    Article Snippet: The human non-small cell lung cancer cell lines PC-9 (kindly gifted from Dr. Kiura, Okayama University, Japan) and A549 (CCL-185, obtained from American Type Culture Collection) were used.

    Techniques: Inhibition